In the present study, an attempt was made to formulate mucoadhesive buccal patches of flurbiprofen (FBN) in order to enhance solubility. Solubity enhancement was attempted by making solid dispersion of drug with -CD (cyclodextrin). Initially preformulation were carried out using reported methods. Buccal patches was prepared by solvent casting technique using polymers like Polyvinyl alcohol (PVA), Sodium carboxymethylcellulose (SCMC), and Hydroxypropyl methyl cellulose (HPMC). The prepared patches were evaluated for their weight variation, thickness, folding endurance, surface pH, swelling index, in-vitro residence time, in-vitro permeation studies, drug content uniformity and bioadhesion test."