In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical "auto-mail" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother's bodies...the legendary Philosopher's Stone.

Hohenheim finally gets his chance to stop the mysterious homunculus father who rules over Central City. Will Hohenheim's surprise be enough to defeat the most powerful homunculus of them all? And when King Bradley makes a triumphant return, will the battle turn in the military's favor...?