Naoki Urasawa's unforgettable thriller follows a brilliant doctor's journey into the darkest depths of the human soul.

Johan is a cold and calculating killer with a mysterious past, and brilliant Dr. Kenzo Tenma is the only one who can stop him! Conspiracy and serial murder open the door to a compelling, intricately woven plot in this masterwork of suspense.

Although Eva bears an unfathomable hatred for Tenma, she is the only person who can testify as a witness to prove his innocence. She stubbornly refuses to do so until a discussion with Dr. Reichwein brings back old memories of her time with Tenma.

With those thoughts come memories of three gunshots, and that it was Johan who Eva saw that night! Meanwhile, the evil hand of Roberto inches steadily closer to Eva with the intent to kill...

Tenma, Nina and Johan all find themselves heading for the one place that holds the key to the mystery--the "Red Rose Mansion." What really happened there and why? Who is Franz Bonaparta? Will the secret of the birth of the Monster ever be revealed?